Given that glycosphingolipid biosynthesis reduces surface level of IFNGR1 and facilitates immune evasion in Kirsten rat sarcoma virus (KRAS)-driven cancer (46), we hypothesized that an analogous mechanism involving glycosphingolipid metabolism contributes to the suppression of IFNGR1 in the context of the RAC1A159V mutation. Here, IFNGR1 is linked to cancer.