Given that different glycosphingolipids and sphingolipids—including glucosylceramide, ceramide 1-phosphate, and ceramide—have the ability to modulate mTOR signaling (48–51), we next examined whether mTOR activation in RAC1A159V tumor cells is mediated by the observed up-regulation of glycosphingolipid biosynthesis. Here, MTOR is linked to neoplasm.