IFNG and neoplasm: Gene sets associated with IFN-γ response—including “HALLMARK_INTERFERON_GAMMA_RESPONSE,” “GOBP_RESPONSE_TO_TYPE_II_INTERFERON,” and “GOBP_CELLULAR_RESPONSE_TO_TYPE_II_INTERFERON”—were also down-regulated in RAC1A159V tumor cells (Fig. 4, C and I), suggesting that the RAC1A159V mutation protects tumor cells from IFN-γ–mediated tumor killing.