S100A4 and neoplasm: S8), a set of metabolic genes—including Slc5a4a, a glucose sensor, and Prg4, a gene associated with glucose utilization (36, 37)—were up-regulated in RAC1A159V tumors, while a set of genes involved in immune functions such as Ifitm1, Pla2g7, S100a4, Gbp4, and H2-Aa, which are crucial for establishing a “hot” tumor microenvironment (38–44), were down-regulated.