Of note, thrombotic microangiopathy is the overarching term used to describe any disease process characterized by thrombocytopenia and microangiopathic hemolytic anemia with or without other clinical or laboratory features (thrombocytopenia, hemolytic anemia with presence of schistocytes in blood smears, decreased haptoglobin level, increased lactate dehydrogenase level and acute kidney injury) [20,21]. The gene discussed is HP; the disease is acute kidney injury.