To further reveal the key mechanism of HO-1 in melanoma development, in vitro studies [112] using ART on A375 melanoma cells revealed that ART selectively reduced the cell viability of melanoma cells without damaging the fibroblasts studied and induced ROS-mediated upregulation of HO-1, resulting in an increase in intracellular Fe2 + levels, further triggering the production of toxic ART free radicals, a novel finding that may open new perspectives for melanoma treatment. Here, HMOX1 is linked to melanoma.