It can be argued that molecular events regulating cell survival, normal growth arrest, apoptosis and cell differentiation play a key role in the overall pathogenesis of melanocyte growth [105].Artesunate had anti-proliferative and pro-apoptotic effects in melanoma A375 cells, and its inhibition of melanoma progression was associated with the expression of transcription factor-3 (STAT3) and related proteins. This evidence concerns the gene STAT3 and melanoma.