Further studies have confirmed that DHA can counteract IL-10-dependent Treg cell inhibition to control CD8CTL function, thereby enhancing anti-tumor immunity in mice [122].In addition to mechanistic studies, how to overcome drug-induced resistance through drug delivery agents or carriers in order to reduce the toxicity of artemisinin derivatives to normal cells and enhance the toxicity to their melanoma cells has become the interest of researchers [123]. This evidence concerns the gene IL10 and melanoma.