The growth and spread of melanoma is also influenced by its surrounding microenvironment, such as immune cells, fibroblasts, and vascular endothelial cells, which are able to evade the surveillance of the immune system through a variety of mechanisms that manipulate cytokines in the tumor microenvironment in order to promote tumor growth and immune escape [38]through the expression of immune-suppressing components, such as PD-L1. The gene discussed is CD274; the disease is melanoma.