HMGCR and cancer: HMG-CoA reductase is the rate-controlling enzyme of the mevalonate lipid metabolic pathway, which plays crucial roles in oncogenesis and cancer cell stemness [60].Melanocytes synthesize cholesterol via HMG-CoA reductase and transport cholesterol via LDL/Apo-B100/LDLR, and cholesterol increases the production of melanocytes and hyperpigmentation-producing melanin in human melanoma cells (FM55) in a time- and dose-dependent manner [61].Cholesterol binds to Orai1, partially inhibiting its activity and decreasing Ca2 + ER/PM influx.