Previous experimental studies using PD models have shown that acupuncture exerts neuroprotective effects through activation of neuroprotective agents such as brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, and cyclophilin A [43], effective in PD symptoms by inducing neuromodulation, thus controlling inflammation and brain functional connectivity [44,45], and p53 signaling-mediated neuroprotective effect [46]. This evidence concerns the gene GDNF and Parkinson disease.