ADAM12 and cardiac hypertrophy: For instance, SPEG is a key regulator of cardiac calcium homeostasis [77–79], ADAM12 inhibition prevents cardiac hypertrophy and its expression has been found to be increased in hypertrophic obstructive cardiomyopathy [80], ITGA6 was shown to be upregulated in patients with peripheral arterial disease [81], and RHOH is involved in coronary artery disease [82].