This begins with lessons learned from studying FOXP2 disruptions that cause childhood apraxia of speech, accompanied by impaired language production and comprehension, before considering how genome or exome sequencing has uncovered pathogenic variants in an array of additional neurodevelopmental genes, including CHD3, DDX3X, KAT6A, SETBP1, SETD1A, WDR5, and ZFHX4. This evidence concerns the gene SETBP1 and apraxia.