In both TB groups (TBD and TBI), cells producing all three cytokines were the most common (median TBD: 37% and TBI: 41%), followed by cells co-producing IFNγ/TNF (median TBD: 20% and TBI: 13%) and IL-2/TNF (median TBD: 10% and TBI: 15%) (Fig. 4A). This evidence concerns the gene IFNG and tuberculosis.