SPP1 and neoplasm: Spatial transcriptomics further validated their immune-evasive phenotype by demonstrating their co-localization with osteopontin-expressing SPP1+ (secreted phosphoprotein 1, also known as osteopontin) macrophages in hypoxic tumor regions that are devoid of CD8+ T cells and enriched for the immune checkpoint molecule HAVCR2 (TIM-3).