Moreover, in transfected cells lamin intensities are always present in contrast to for instance p16 reporters which, although reliably monitor senescent cells in mice,[49, 50] suffer from poor performance in many cancers due to mutated or absent p16‐expression.[51, 52] Our reporter system is compatible with both imaging live and fixed cells, and we developed variants with different fluorophore combinations to suit specific applications, including FACS. Here, CDKN2A is linked to cancer.