Notably, CRL5 has been implicated in mediating resistance to CDK9 and MCL1 inhibitors in lung cancer cells by targeting pro‐apoptotic proteins NOXA and BIM for degradation.[60] Our findings extend this role by showing that CUL5 also promotes resistance to the anti‐microtubule agent paclitaxel, which stabilizes microtubules, by delaying mitotic exit. This evidence concerns the gene PMAIP1 and lung carcinoma.