CUL5 and familial pancreatic carcinoma: Its dysfunction has been implicated in several human diseases, particularly cancer.[16, 17] To fully elucidate the role of CRL5 in physiological and pathological processes, we first generated pancreatic cancer MIA PaCa‐2 cells that stably express CUL5, tagged with a tandem streptavidin‐binding peptide (SBP) and an S tag.