miR‐93‐5p is an oncomiR that can activate the PI3K/Akt pathway, being involved in cancer cell proliferation, invasion, and resistance to apoptosis.[36, 37] It also acts as a target key regulator of the epithelial‐mesenchymal transition and Wnt signaling pathways.[38] In line with these reports, our bioinformatics and luciferase reporter assays demonstrated that RBC‐derived miR‐93‐5p directly targets tumor suppressors such as PTEN, TP53INP1, THBS2, and CDKN1A. This evidence concerns the gene TP53INP1 and neoplasm.