In summary, this study uncovered that a prevalent virus worldwide, ToCV, modulates PG in chloroplasts to impair α‐tocopherol biosynthesis via targeting FBN1.1, leading to lipid oxidation, which is sensed by SAL1, triggering the SAL1‐PAP retrograde signaling pathway, thereby facilitating infection and improving host drought tolerance. Here, SALL1 is linked to infection.