While several studies suggest a positive association between hs-CRP levels and the incidence or severity of DR, others have reported inconsistent or even inverse relationships, highlighting the need for further investigation.11-13 This study aims to evaluate the association between hs-CRP plasma levels and DR in patients with T2DM to gain a clearer understanding of the role of inflammation and endothelial damage in the pathogenesis of DR. The gene discussed is CRP; the disease is type 2 diabetes mellitus.