PFKFB3 is necessary for cancer cell migration and can be activated downstream of the EGF receptor (EGFR) by extracellular signal-regulated kinase (ERK), AMP-activated kinase (AMPK) or protein kinase A (PKA) signaling (Fig. 4A) (Shi et al., 2017). The gene discussed is PFKFB3; the disease is cancer.