TIMP1 and Gliosis: 1. ECM remodeling: Regulates the synthesis and degradation of components such as collagen and fibronectin, maintaining the stability of the matrix structure; 2. Gliosis inhibition: Reduces the deposition of chondroitin sulfate proteoglycans (CSPG), inhibits the activation of type A astrocytes; 3. Microenvironment improvement: Regulates matrix metabolism through the balance of MMPs/TIMP, creating a favorable environment for neural regeneration; 4. Barrier protection: Regulates proteins related to the blood-brain-spinal cord barrier, reducing ECM damage.