The diagram of the mediation effect of MoCA in the relationship between MDS-UPDRS III score and PDA (L/R) are shown in Figures 3A,B, and the regression analysis among the variables are shown in Table 3, indicating that MDS-UPDRS III score had a negative relationship with PDA (L/R) and MoCA, but MoCA had no relationship with PDA (L/R). The gene discussed is DOCK3; the disease is Patent ductus arteriosus.