In univariate analysis, previous cardiac disease (HR 2.61, 95% CI 1.41-4.82, p = 0.001), and baseline ammonia (HR 1.01, 95% CI 1.01-1.02, p <0.001) and albumin (HR 0.90, 95% CI 0.85-0.96, p <0.001) levels were significantly associated with post-TIPS OHE occurrence, whereas patients treated with rifaximin (HR 0.41, 95% CI 0.21-0.79, p = 0.008) experienced significantly less OHE episodes after TIPS. This evidence concerns the gene ALB and heart disorder.