While PD-L1 expression correlates with response in cancers such as NSCLC, ESCC, and urothelial carcinoma, it has shown inconsistent or no correlation in others, including breast cancer, glioblastoma, and HNSCC (105, 106, 114, 136, 139, 146, 164). This evidence concerns the gene CD274 and non-small cell lung carcinoma.