Figure 7H showed the expression of key TFs across subpopulations. RUNX3, the leading TF in C2 CXCR4+ Fibroblast, was linked to EM malignant transformation through hypermethylation (52). Additional analysis found RUNX3 had the highest specificity in the G2M phase and exhibited elevated expression in Endometriomas compared to Endometriosis (Figures 7F–H), indicating its potential as a therapeutic target. Here, CXCR4 is linked to endometriosis.