NOS2 and urinary bladder cancer: Another investigation found that, CXCL2/MIF-CXCR2 pathway increased and enhanced recruitment of MDSCs in bladder cancer which produces high immunosuppressive molecules including Arg1 (arginase 1), iNOS (inducible nitric oxide synthase), PD-L1 (Programmed death-ligand 1) and P-STAT3 (266).