Additional direct and via partners PPI were noted among BGLAP (Bone Gamma-Carboxyglutamate Protein), RUNX2 (RUNX Family Transcription Factor 2), ENPP1 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 1), and ALPL interacting in the endochondral ossification with skeletal dysplasias, endochondral ossification, OSX and miRNAs in tooth development, and FGF23 signaling in hypophosphatemic rickets and related disorders pathways (Figure 1). The gene discussed is ALPL; the disease is skeletal dysplasia.