The study suggests that HXL131 exposure increased DUSP1, CYR61, TIMP1, SOD2, IL-6, SERPINE2, TNFSF9, OSMR, TNFRSF10D, and TNFRSF12A proteins that participate in PCa cell activity inhibition, whereas, the molecular docking and cellular thermal shift assay indicate that HXL131 shows strong binding affinity with DUSP1 and TNFSF9, suggesting that targeting DUSP1 by HXL131may be useful to control PCa growth and metastasis.87 Here, TNFRSF10D is linked to posterior cortical atrophy.