DUSP4 and breast cancer: Knockdown of DUSP1, DUSP4, and DUSP6 involved in the formation of CD44hi/CD24lo/EpCAM+ breast CSCs, and importantly DUSP1 knockdown reduces CSC formation, while DUSP4 and DUSP6 knockdown enhance CSC formation, suggesting that DUSPs modulate EMT and CSC regulation in breast cancer differentially.119