On the other hand, DUSP1 levels are undetectable in high-grade prostatic neoplasia and prostatic adenocarcinoma tissues, where high expression of nuclear p65/NF-κB and activated p38 was found, suggesting that DUSP1 levels may modulate PCa development and progression differently in different stages of prostate cancer.13 This evidence concerns the gene DUSP1 and Familial prostate cancer.