Enhance P2X7 receptor expression by downregulation of the p38 pathway in neuroblastoma cells,160 and exert cytotoxicity after deletion of DUSP6 and DUSP1 (CRISPR-Cas9) in neuroblastoma cells, suggesting that BCI cytotoxicity does not depend on DUSP1 or DUSP6 status in neuroblastoma cells.161. The gene discussed is P2RX7; the disease is neuroblastoma.