Knockdown of DUSP1, DUSP4, and DUSP6 involved in the formation of CD44hi/CD24lo/EpCAM+ breast CSCs, and importantly DUSP1 knockdown reduces CSC formation, while DUSP4 and DUSP6 knockdown enhance CSC formation, suggesting that DUSPs modulate EMT and CSC regulation in breast cancer differentially.119. This evidence concerns the gene DUSP6 and breast cancer.