On the other hand, DUSP1 levels are undetectable in high-grade prostatic neoplasia and prostatic adenocarcinoma tissues, where high expression of nuclear p65/NF-κB and activated p38 was found, suggesting that DUSP1 levels may modulate PCa development and progression differently in different stages of prostate cancer.13 The gene discussed is NFKB1; the disease is Familial prostate cancer.