In addition, the study demonstrated that cisplatin cytotoxicity is associated with ERK-MAPK activation, and interestingly, DUSP1 inactivation (by inhibitor) enhanced both cisplatin-stimulated ERK phosphorylation and OC tumor cell death, suggesting that FAK expression and nuclear localization curtail cisplatin cytotoxicity by DUSP1-mediated noncanonical ERK/MAPK activation.129. Here, MAPK1 is linked to neoplasm.