DUSP1 and posterior cortical atrophy: DUSP1 overexpression increased cell proliferation in PC3 PCa cells by inhibition of MAPK signaling (blocking the phosphorylation of p38 MAPK), and silencing DUSP1 activated MAPK signaling and increased cell proliferation, suggesting that DUSP1 expression is associated with SCCP progression and may be a potential therapeutic target for SCCP treatment.83