,133,134 Overexpression of DUSP1 was found to inhibit the JNK protein (which belongs to the MAPK pathway), and impede mechlorethamine, doxorubicin, paclitaxel, and doxorubicin + mechlorethamine-mediated apoptosis in breast cancer in vivo.118. The gene discussed is MAPK8; the disease is breast carcinoma.