DUSP1 and colorectal cancer: In the colorectal cancer mouse model, DUSP1 knockout shows activation of cell adhesion, ion transport, extracellular matrix organization, response to the drug [azoxymethane/dextran sodium sulfate (AOM/DDS)], response to hypoxia, and response to toxic substances, suggesting that DUSP1 is associated with CRC development and metastasis.105