DUSP1 and non-small cell lung carcinoma: On the other hand, histone deacetylases (HDACs), an onco-protein, also control DUSP1 expression, and knockdown of HDAC induces DUSP1 expression, DISP1 upregulation inhibits EGFR signaling, and restores gefitinib sensitivity in NSCLC in vitro and in vivo.100