In contrast, CC398 strains harbored cna, encoding a collagen-binding protein linked to osteomyelitis and arthritis (Madani et al., 2017), and a hysA homolog within νSaβ type V, previously detected in a human LA-MRSA ST398 endocarditis case and associated with greater virulence than CC1/ST9 (Ji et al., 2021). Here, PPP3CA is linked to osteomyelitis.