PRDX2 and cancer: PRDX2 plays a dual role in tumorigenesis, acting as either a tumor suppressor or promoter depending on cellular context, with its expression influenced by etiology, cancer type, and tumor stage.37, 38, 39, 40 In melanoma, decreased PRDX2 expression promotes tumor growth and is linked to epithelial–mesenchymal transition and β-catenin signaling activation.40