Inducing tumor cell cycle arrest is an effective method, and common clinical chemotherapeutic agents such as gemcitabine, cisplatin, and vinorelbine exhibit anti-tumor efficacy by breaking the cell cycle.26, 27, 28 In this study, we found that administering VER led to G0/G1 phase cell cycle arrest in 143B and HOS cell lines, subsequently reducing the expression of cyclin D1 associated with the G1 phase. Here, CCND1 is linked to neoplasm.