HK2 and glioblastoma: Notably, in a clinical trial involving five patients with GBM, three showed tumor regression on MRI scans after DCA treatment, while four maintained stable disease at 15 months and remained alive at the 18-month follow-up.‍43 We observed that ATAD2 could also regulate the expression of metabolism-related proteins, including HK2, GLUT1, and MCT4.