Patients with higher Lp(a) levels at baseline had a significantly higher risk of severe AS (OR: 1.78; 95% CI: 1.18–2.66, P 0.006) On follow-up (mean 3.16 ± 2.74 yrs), Lp(a) was not associated with AVR or death from AVS. The gene discussed is LPA; the disease is aortic valve stenosis.