INS and type 2 diabetes mellitus: Additionally, T2DM can cause many complications, including central nervous system diseases such as Alzheimer’s disease [3] as well as retinopathy, diabetic kidney disease, and peripheral neuropathy as microvascular diseases. Although a glycemic goal of 80-110 mg/dL with insulin reduced mortality by 40% compared with a standard glycemic goal of 180-215 mg/dL, hypoglycemia occurred at 10- to 15-fold higher rates [4].