TARDBP and amyotrophic lateral sclerosis: Oral administration of Cu (II)(atsm) in SOD1G93A mice reduces oxidative and nitrosative damage and prevents the accumulation of abnormally phosphorylated and fragmented TAR DNA-binding protein-43 (TDP-43) in the spinal cord, a key protein involved in ALS progression (Soon et al., 2011) (Table 2).