We identified potential associations between ovarian cancer risk and thepolymorphisms rs743572(NM_000102.4(CYP17A1):c.−34T>C), rs4680(NM_000754.4(COMT):c.472G>A (p.Val158Met)), and rs1695(NM_000852.3:(GSTP1):c.313A>G (p.Ile105Val)).Specifically, the C allele of rs743572 (OR = 1.54; 95% CI (1.29–1.84))was associated with an increased risk of ovarian cancer. Here, COMT is linked to ovarian carcinoma.