Blood lipid abnormalities: Total Cholesterol (TC) ↑; Triglycerides (TG)↑; Low-Density Lipoprotein Cholesterol (LDL-C) ↑; High-Density Lipoprotein Cholesterol (HDL-C) ↓; ApoB/ApoA1 ↑.Disease risk: Accelerates atherosclerosis, increasing the risk of cardiovascular and cerebrovascular events, peripheral vascular disease, and acute coronary syndrome;Increases the risk of non-alcoholic fatty liver disease (NAFLD). The gene discussed is APOA1; the disease is metabolic dysfunction-associated steatotic liver disease.