For instance, Chen et al. discovered the CircZFR-miR-3127-5p/RTKN2 pathway in CRC, Hong et al. identified the CircZFR-miR-1261/C8orf4 pathway in TC, and the CircZFR-miR-101-3p/CUL4B pathway in NSCLC (Chen et al., 2024; Wei et al., 2018; H. Zhang et al., 2019). Here, RTKN2 is linked to colorectal carcinoma.