HIF1A and breast cancer: Chen Zhuo et al. discovered that CircZFR functions as a molecular sponge by binding to and inhibiting miR-578, thereby relieving its suppression of the downstream target gene HIF1A.By adsorbing and inhibiting miR-578, it relieves its suppression of the downstream target gene HIF1A, thereby promoting BC cell survival, clonogenic formation, migration, invasion, and glycolysis while inhibiting apoptosis.