FOXO4 and colorectal carcinoma: Additionally, CircZFR is associated with miR-532-3p, which promotes apoptosis and inhibits cell cycle progression in CRC cells by regulating the transcription of downstream FOXO4; However, CircZFR also promotes CRC cell proliferation and metastasis by modulating the miR-3127-5p/RTKN2 and miR-147a/CACUL1 axes (Chen et al., 2024; Du et al., 2017; Tan et al., 2022).