Chen’s research identified 16 differentially expressed genes (DEGs) for HF using random forests, which included ECM2, LUM, ISLR, ASPN, PTN, SFRP4, GLT8D2, FRZB, FCN3, TEAD4, NPTX2, LAD1, ALOX5AP, RNASE2, IL1RL1, and CD163 (Chen et al., 2023). This evidence concerns the gene IL1RL1 and hydrops fetalis.