SFRP4 and hydrops fetalis: Chen’s research identified 16 differentially expressed genes (DEGs) for HF using random forests, which included ECM2, LUM, ISLR, ASPN, PTN, SFRP4, GLT8D2, FRZB, FCN3, TEAD4, NPTX2, LAD1, ALOX5AP, RNASE2, IL1RL1, and CD163 (Chen et al., 2023).