Chen’s research identified 16 differentially expressed genes (DEGs) for HF using random forests, which included ECM2, LUM, ISLR, ASPN, PTN, SFRP4, GLT8D2, FRZB, FCN3, TEAD4, NPTX2, LAD1, ALOX5AP, RNASE2, IL1RL1, and CD163 (Chen et al., 2023). The gene discussed is ISLR; the disease is hydrops fetalis.