Initially, 81 common HF candidate Hub genes were analyzed by single-gene differential analysis across these datasets, which led to the identification of three DEGs: ASPN, COL14A1, and MYH6, of which ASPN and COL14A1 were upregulated in HF, while MYH6 was downregulated (Figure 5A). This evidence concerns the gene ASPN and hydrops fetalis.