SMCHD1 and facioscapulohumeral muscular dystrophy 2: Furthermore, SMCHD1 restricts herpesvirus replication by binding viral lytic origins and inhibiting replication complexes; mutations in SMCHD1 cause facioscapulohumeral muscular dystrophy type 2 (FSHD2) through aberrant gene silencing (Tian et al., 2023).