Through MR analysis under three predefined screening criteria (Supplementary Table S7), we established RLF and SMCHD1 as causal risk genes significantly elevated in MI patients The key MR analyses—including leave-one-out sensitivity (Figures 2A,D), genetic association scatter plots (Figures 2B,E), and the forest plot of the combined IVW estimates (Figure 2H)—visually confirm the robust causal effects of RLF and SMCHD1 on MI risk. Here, SMCHD1 is linked to myocardial infarction.