This association remained significant in Model I (adjusted for age, sex and BMI) [HR 1.09 (1.05, 1.14), P < .001] and Model II (further adjusted for age, sex, BMI, months on dialysis, hemoglobin, CK-MB, BNP, uric acid, total cholesterol, triglycerides, type of dialysis vascular access, hypertension and diabetes mellitus) [HR 1.07 (1.01, 1.13), P = .020]. This evidence concerns the gene NPPB and diabetes mellitus.