Anxiety, depression, stress, patient, pain, placebo, Perimenopausal, postmenopasual symptoms, menopausal syndrome, relationship, severity, symptom, climacteric, behavioural, woman, HPA, HPO, hormonal changes, menopausal transition, FSH, LH, Inhibin, progesterone, estrogen. This evidence concerns the gene PLOD1 and depressive disorder.