Anxiety, depression, stress, patient, pain, placebo, Perimenopausal, postmenopasual symptoms, menopausal syndrome, relationship, severity, symptom, climacteric, behavioural, woman, HPA, HPO, hormonal changes, menopausal transition, FSH, LH, Inhibin, progesterone, estrogen. This evidence concerns the gene PLOD1 and depressive symptom measurement.