Anxiety, biomarkers, inflammation, antioxidants, depression, experimental trials, clinical trials, neuro-inflammation, menopausal syndrome, BDNF, Interleukin, roots, superoxide, symptom, woman, BDR, brain, symptom, PMS, protein, ROS, woman, MDD, IL-8, TNF-α, MAPK, RNS, Nrf2, estrogen, cGMP. This evidence concerns the gene TNF and major depressive disorder.