The search strategy combined MeSH terms and free-text words, including “Glucagon-Like Peptide 1 [MeSH]”, “GLP-1′′, “Semaglutide”, “Liraglutide”, “Saxenda”, “Tirzepatide”, “Albiglutide”, “Exenatide”, “Dulaglutide”, “Beinaglutide”, “Polyethylene glycol loxenatide”, “Lixisenatide”, “Loxenatide”, “Mashidutide”, paired with “Osteoarthritis, knee [MeSH]”, “Degeneration of the knee”, “Knee joint”, “Knee OA”, and “KOA”. This evidence concerns the gene GCG and osteoarthritis.