CREB1 and osteoarthritis: Temporally, liraglutide induced rapid (≤7 days) and sustained (≥28 days) benefits (Meurot et al., 2022), correlating with GLP-1 receptor/PKA/CREB activation, while untreated osteoarthritis saw progressive GLP-1 receptor decline (nadir at day 20) (Que et al., 2019).