WSP exhibited notable pharmacological effects by improving bone mass/quality and serum calcium/phosphorus levels in diet-induced PMOP mice, mediated via upregulating key calcium transport proteins: transient receptor potential vanilloid 5 (TRPV5) and calcium-binding protein (CABP) in the kidney, transient receptor potential vanilloid 6 (TRPV6) and CABP in the ileum, and vitamin D receptor (VDR) in the femur; moreover, WSP reversed PMOP-associated anemia and facilitated tissue structural repair in the kidney, ileum, and femur. Here, TRPV5 is linked to anemia.