CDKN2A, MTF1, LIAS, GLS, FDX1 and CDKN2A have been highlighted as the regulators of cuproptosis, with its expression correlating with poor survival outcomes in cancers (Zhang et al., 2023a; Wu et al., 2025; Zuo et al., 2025; Zhang R. et al., 2024). Here, CDKN2A is linked to cancer.