Dehydrocostus lactone from ALD inhibits viability, migration, and proliferation of laryngeal carcinoma cells (Hep-2 and TU212) with low toxicity to normal HBE cells, and suppresses tumor growth in vivo by inducing mitochondrial apoptosis via inhibiting PI3K/Akt/Bad and activating ER stress pathways. This evidence concerns the gene AKT1 and neoplasm.