ACSL3 promotes HCC cell proliferation by reprogramming fatty acid metabolism, particularly by catalyzing the production of monounsaturated fatty acids (MUFAs) used for membrane synthesis and energy storage (Li et al., 2023; Cai et al., 2023). It also contributes to HCC progression by modulating cholesterol homeostasis, which affects the tumor microenvironment and signaling pathways (Huang et al., 2023). This evidence concerns the gene ACSL3 and hepatocellular carcinoma.