Further analysis of the annotation within this state, enriched for AD heritability and comprising the bottom 200 genes with the most negative loadings in PC6, identified genome-wide significant markers for AD, including APP (ranked 195/200), a precursor to amyloid-beta plaques, and HERC1 (ranked 112/200), associated with protein degradation and inflammation. Here, HERC1 is linked to Alzheimer disease.