[14]’s study found that the AA genotype of the interferon-gamma (IFNG or IFN-γ) gene, which was present in 60% of their LC cohort, led to a lower expression of the cytokine IFN-γ, potentially leading to an impaired immune system, allowing for a higher level of inflammation to occur. The gene discussed is IFNG; the disease is laryngotracheoesophageal cleft.