ACE2 and infection: Overexpression of ACE2 increased susceptibility to SARS-CoV-2 S-mediated infection in the differentiated subcutaneous cells (ACE2-SNPAD-B) bringing levels up to those seen in the parental visceral VNPAD-30315 cells, suggesting that the lower levels of infection in the parental subcutaneous SNPAD B cells as compared to the parental visceral VNPAD-30315 cells are due to lower ACE2 in the subcutaneous cells (Figure 3).