These persistent reservoirs of viruses and vRNA may be capable of being translated to continuously produce viral protein antigens, either locally in affected organs, or distantly released into the circulation, thereby inducing both local and systemic inflammation, immune cells overstimulation, as well as the exhaustion of CD4+ and CD8+ T cells in a subset of patients with LC [23,35,38,39,40,41,42] (Figure 2 and Figure 3). This evidence concerns the gene CD8A and laryngotracheoesophageal cleft.