Below, we will review the growing body of clinical evidence that persistent reservoirs of virus, persistent vRNA, and, in some cases, persistent SARS-CoV-2 antigens in multiple organs of patients with LC, which may cause chronic inflammation and dysfunction (exhaustion) of antiviral CD4+ and CD8+ T cells associated with various symptomatology of LC [35,38,39,40,41,42]. The gene discussed is CD4; the disease is laryngotracheoesophageal cleft.