This model has four attributes: (1) susceptibility to SARS-CoV-2 infections [209,210]; (2) development of both pulmonary, behavioral and neurological manifestations that mimic those seen in patients with LC; (3) development of T cell responses to HLA-restricted human CD4+ and CD8+ T cell epitopes from multiple SARS-CoV-2 antigens; (4) quantifiable virus and vRNA reservoirs in multiple organs. Here, CD8A is linked to laryngotracheoesophageal cleft.