For instance, EBV infection has been shown to induce stem-like properties in B-cells through latent membrane protein LMP-1-mediated activation of Wnt/β-catenin and Notch signaling pathways, creating self-renewing populations that seed post-transplant lymphoproliferative disorders (PTLDs) [222]. The gene discussed is PDLIM7; the disease is lymphoproliferative syndrome.