ERN1 and Zika virus infectious disease: Considering the induction of ER stress during infection together with the critical role of IRE1 in ZIKV replication in human cell models such as HeLa and A549 cells [42,43], we evaluated the activation of IRE1α (hereafter referred as IRE1) endonuclease activity during ZIKV infection at 24 and 48 hpi in the C20 human microglia cell line.