ERN1 and Zika virus infectious disease: Although we acknowledge that the use of a microglia cell line instead of a primary culture and/or microglia derived from iPSCs represents a limitation, our work provides novel insights into the complex interplay between ZIKV infection, the ER stress sensor IRE1 and the antiviral response in humans, highlighting the potential of IRE1 as a target for the development of antivirals to treat ZIKV infections.