Pathways such as thyroid hormone receptor and retinoid X receptor (TR/RXR) activation, phosphatase and tensin homolog (PTEN) regulation, macrophage classical activation, and growth arrest and DNA damage-inducible 45 (GADD45) signaling were activated as early as day 3 post-infection and persisted until day 9 post-infection. The gene discussed is PTEN; the disease is infection.