NR3C2 and heart failure: The 4 pillars of heart failure have been very well cemented by numerous studies and include ACE inhibitors/ARBs (angiotensin II receptor blockers)/ARNI (angiotensin II receptor-neprilysin inhibitor), mineralocorticoid receptor antagonists (MRA), sodium glucose co-transporter-2 inhibitors (SGLT2i) and beta-blockers.