Rein-Smith et al. [23] conducted an in vitro study using HepG2 human hepatocellular carcinoma cells (derived from a well-differentiated hepatocellular carcinoma in a 15-year-old Caucasian male, it is widely used as a hepatocyte model because it retains liver-specific functions and shows IL-6–responsive expression of acute-phase proteins, including fibrinogen and TPO) to assess the direct effect of IL-6 on fibrinogen gene expression. This evidence concerns the gene TPO and hepatocellular carcinoma.